Retinoic acid metabolic process

Across TCGA patient cohorts, RNA activity of the Retinoic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBP1, ZFP62, and DDX17, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinoic acid metabolic process activity versus RBP1 in SCLC (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	RBP1 →	+1.924	+0.199	.002	.004	2	25
TGCT	ZFP62 →	-0.655	-0.069	<.001	<.001	3	22
DLBC	DDX17 →	-0.892	-0.063	<.001	<.001	2	22
SARC	KHDC4 →	-0.639	-0.046	<.001	<.001	3	21
DLBC	CCDC66 →	-0.859	-0.048	<.001	.006	3	21
GBM	CAPN10-DT →	-0.577	-0.067	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042573 vs RBP1 — SCLC

Explore this scatter interactively →