Retinoic acid metabolic process

Across TCGA patient cohorts, RNA activity of the Retinoic acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C3, TPR, and ADH1C, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinoic acid metabolic process activity versus AKR1C3 in LSCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C3 →	+1.648	+0.100	<.001	<.001	3	9
BRCA	TPR →	-0.193	-0.033	.001	<.001	3	6
UCEC	ADH1C →	+1.251	+0.082	<.001	<.001	3	6
COAD	GPKOW →	-0.206	-0.049	.001	.006	3	6
UCEC	HSPB8 →	+0.781	+0.085	<.001	<.001	3	6
UCEC	TRRAP →	-0.195	-0.098	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042573 vs AKR1C3 — LSCC

Explore this scatter interactively →