Retinoic acid metabolic process

Across TCGA patient cohorts, RNA activity of the Retinoic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RDH10, NDRG2, and CES1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinoic acid metabolic process activity versus RDH10 in LSCC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RDH10 →	+1.225	+0.228	<.001	<.001	3	6
LSCC	NDRG2 →	+0.668	+0.167	.003	.003	3	6
OV	CES1 →	+1.361	+0.242	.001	.005	3	5
HNSC	DHRS9 →	+1.648	+0.286	<.001	<.001	3	5
GBM	MCM3 →	-0.511	-0.148	<.001	<.001	3	5
OV	IGHA2 →	+2.632	+0.298	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042573 vs RDH10 — LSCC

Explore this scatter interactively →