Retinoic acid metabolic process

Across TCGA cell cohorts, RNA activity of the Retinoic acid metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBP1, CYP26B1, and UGT1A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBP1 grouped by Retinoic acid metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RBP1 →	-0.482	-1.461	<.001	<.001	3	6
CNS	CYP26B1 →	-0.250	-1.049	.006	.001	2	6
BLOOD_Leukemia	UGT1A1 →	-0.213	-1.082	.003	.001	3	5
CNS	CYP26C1 →	-0.189	-0.752	.005	.007	3	5
BLOOD_Myeloma	UBL4B →	-0.248	-1.601	.004	.002	2	5
URINARY_TRACT	STYXL2 →	+0.215	+1.890	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBP1 by Retinoic acid metabolic process activity — OVARY

Explore this box plot interactively →