Retinol metabolic process

Across TCGA patient cohorts, RNA activity of the Retinol metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RDH10, WIZ, and AKR1C2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinol metabolic process activity versus RDH10 in UCEC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RDH10 →	+0.789	+0.071	<.001	<.001	3	7
UCEC	WIZ →	-0.218	-0.073	.002	<.001	3	7
LSCC	AKR1C2 →	+2.145	+0.072	<.001	<.001	3	7
LSCC	AKR1C3 →	+1.692	+0.057	<.001	.001	3	7
LSCC	KIAA1522 →	+0.325	+0.042	<.001	<.001	3	7
OV	SVIL_S707 →	+0.731	+0.033	.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042572 vs RDH10 — UCEC

Explore this scatter interactively →