Retinol metabolic process

Across TCGA patient cohorts, RNA activity of the Retinol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALMS1, SFXN1, and ADH1C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinol metabolic process activity versus ALMS1 in HNSC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ALMS1 →	-0.450	-0.219	.007	<.001	3	6
BRCA	SFXN1 →	-0.557	-0.241	<.001	<.001	3	6
LSCC	ADH1C →	+1.758	+0.120	.003	.002	3	6
LSCC	C16orf89 →	+1.931	+0.175	<.001	<.001	3	5
GBM	NCF1C →	+0.798	+0.216	<.001	<.001	3	5
GBM	MAGEF1 →	-0.416	-0.157	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042572 vs ALMS1 — HNSC

Explore this scatter interactively →