Retinol metabolic process

Across TCGA cell cohorts, RNA activity of the Retinol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RDH10, ERCC3, and E2F3, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinol metabolic process activity versus RDH10 in SOFT_TISSUE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RDH10 →	+2.987	+0.175	<.001	<.001	3	13
LARGE_INTESTINE	ERCC3 →	-0.707	-0.104	<.001	<.001	3	11
BONE	E2F3 →	-0.658	-0.111	.008	.002	3	11
STOMACH	KIF14 →	-1.202	-0.144	<.001	.002	3	11
URINARY_TRACT	HSF2 →	-0.756	-0.162	<.001	<.001	3	11
LARGE_INTESTINE	BUB1 →	-0.704	-0.092	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042572 vs RDH10 — SOFT_TISSUE

Explore this scatter interactively →