Retinol metabolic process

Across TCGA cell cohorts, RNA activity of the Retinol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFAF6, TGFA, and GPR35, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinol metabolic process activity versus NDUFAF6 in URINARY_TRACT (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NDUFAF6 →	+1.005	+1.816	.005	.006	3	5
SKIN	TGFA →	-2.842	-0.354	<.001	.005	3	5
BLOOD_Myeloma	GPR35 →	+1.969	+0.295	.005	.001	2	5
OESOPHAGUS	NARS1 →	+1.005	+0.339	<.001	<.001	3	4
LIVER	IDH1 →	+1.677	+0.428	.001	<.001	3	4
LIVER	GSR →	+1.198	+0.428	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042572 vs NDUFAF6 — URINARY_TRACT

Explore this scatter interactively →