Pteridine-containing compound biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pteridine-containing compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRAMD2B, RPA3, and PTS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pteridine-containing compound biosynthetic process activity versus GRAMD2B in PDAC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	GRAMD2B →	+0.280	+0.138	.006	.001	3	4
UCEC	RPA3 →	+0.490	+0.172	.002	.003	3	3
OV	PTS →	+0.501	+0.168	.005	.006	2	4
PDAC	LINC02888 →	+0.650	+0.168	.004	.001	3	3
COAD	RASD2 →	-0.746	-0.239	.004	.002	3	3
BRCA	MIR1273C →	-0.372	-0.155	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042559 vs GRAMD2B — PDAC

Explore this scatter interactively →