Pteridine-containing compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pteridine-containing compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEPTIN7, RECK, and AJUBA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEPTIN7 grouped by Pteridine-containing compound biosynthetic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SEPTIN7 →	-0.645	-1.741	.003	<.001	2	6
BREAST	RECK →	-1.390	-0.990	.003	.004	3	5
LUNG_SCLC	AJUBA →	-1.893	-1.048	.005	.002	2	5
KIDNEY	TGM2 →	-2.288	-1.240	.005	.009	3	4
BREAST	HOXA1 →	-0.624	-0.826	.005	<.001	3	4
BREAST	ARL10 →	-0.789	-0.943	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEPTIN7 by Pteridine-containing compound biosynthetic process activity — BONE

Explore this box plot interactively →