Pteridine-containing compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pteridine-containing compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ING5, RPIA, and AP1AR, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pteridine-containing compound biosynthetic process activity versus ING5 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ING5 →	+0.898	+1.188	.007	.005	3	7
LUNG_SCLC	RPIA →	+0.662	+0.173	.006	.007	1	9
STOMACH	AP1AR →	+0.952	+0.339	<.001	.001	3	6
PANCREAS	ANXA8L1 →	-2.860	-0.302	.003	.001	3	6
URINARY_TRACT	FARP2 →	+0.665	+0.461	.002	.002	3	6
BLOOD_Lymphoma	CLUH →	+1.396	+0.219	.003	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042559 vs ING5 — UPPER_AERODIGESTIVE_TRACT

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