Pteridine-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Pteridine-containing compound metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDC20_T70, RRP36_S73, and WDR36, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pteridine-containing compound metabolic process activity versus CDC20_T70 in OV (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CDC20_T70 →	+1.109	+0.038	<.001	<.001	3	7
UCEC	RRP36_S73 →	+0.609	+0.052	<.001	<.001	3	6
UCEC	WDR36 →	+0.249	+0.041	<.001	<.001	3	6
LSCC	MSH2 →	+0.422	+0.036	.003	.003	3	6
LSCC	COL1A2 →	-0.596	-0.044	<.001	<.001	3	6
UCEC	TBL3 →	+0.277	+0.059	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042558 vs CDC20_T70 — OV

Explore this scatter interactively →