Pteridine-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Pteridine-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEROX1, CENPH, and LOX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pteridine-containing compound metabolic process activity versus CEROX1 in GBM (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CEROX1 →	-1.092	-0.187	.002	<.001	3	4
LUAD	CENPH →	+0.573	+0.148	<.001	<.001	3	4
CCRCC	LOX →	+1.243	+0.176	<.001	.002	3	3
CCRCC	PLBD1 →	+0.448	+0.143	.001	.002	3	3
CCRCC	BCAS4 →	+0.366	+0.164	.001	.001	3	3
GBM	SRD5A1 →	+0.439	+0.172	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042558 vs CEROX1 — GBM

Explore this scatter interactively →