Pteridine-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Pteridine-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFL2, TUBB6, and RILPL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CFL2 grouped by Pteridine-containing compound metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFL2 →	-2.589	-1.302	<.001	<.001	3	6
BREAST	TUBB6 →	-2.117	-0.934	.001	.001	3	6
LARGE_INTESTINE	RILPL1 →	-1.148	-1.122	.004	.002	3	5
URINARY_TRACT	SNX19 →	-1.235	-1.368	.006	<.001	3	4
URINARY_TRACT	YAP1 →	-1.454	-1.364	.008	.005	3	4
URINARY_TRACT	SLC39A13 →	-1.034	-1.464	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CFL2 by Pteridine-containing compound metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →