Superoxide anion generation

Across TCGA cell cohorts, RNA activity of the Superoxide anion generation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRI1, ZNF317, and QTRT2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KRI1 grouped by Superoxide anion generation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KRI1 →	-1.023	-1.062	<.001	<.001	3	4
OVARY	ZNF317 →	-0.660	-1.049	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	QTRT2 →	-1.118	-1.077	<.001	<.001	3	4
SOFT_TISSUE	ATG3 →	-0.741	-1.488	.004	.001	3	4
LARGE_INTESTINE	WDR18 →	-0.752	-1.653	.001	<.001	3	4
PANCREAS	SP4 →	-0.561	-1.237	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KRI1 by Superoxide anion generation activity — OVARY

Explore this box plot interactively →