Neuron maturation

Across TCGA patient cohorts, RNA activity of the Neuron maturation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL4, RPL3, and RPL10A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron maturation activity versus RPL4 in GBM (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL4 →	-0.351	-0.052	<.001	<.001	3	7
GBM	RPL3 →	-0.322	-0.049	<.001	<.001	3	6
OV	RPL10A →	-0.208	-0.024	.007	.003	2	7
GBM	RPL11 →	-0.261	-0.059	<.001	<.001	3	6
GBM	RPL5 →	-0.209	-0.046	<.001	<.001	3	6
OV	RPL7A →	-0.313	-0.027	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042551 vs RPL4 — GBM

Explore this scatter interactively →