Neuron maturation

Across TCGA patient cohorts, RNA activity of the Neuron maturation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEPTIN7, UACA, and CBR3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron maturation activity versus SEPTIN7 in PDAC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SEPTIN7 →	-0.262	-0.519	.001	<.001	3	4
PDAC	UACA →	-0.523	-0.553	<.001	<.001	3	4
PDAC	CBR3 →	-0.260	-0.350	.008	.006	3	4
GBM	GPX8 →	-0.781	-0.629	<.001	.004	3	4
COAD	RNF181 →	-0.433	-0.620	<.001	<.001	3	4
GBM	MRPS9-AS1 →	+0.260	+0.750	.008	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042551 vs SEPTIN7 — PDAC

Explore this scatter interactively →