Neuron maturation

Across TCGA cell cohorts, RNA activity of the Neuron maturation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CST6, SDC4, and SCLY, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron maturation activity versus CST6 in LUNG_NSCLC_LUAD (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CST6 →	+2.881	+1.026	.003	.001	3	5
STOMACH	SDC4 →	+3.136	+1.545	.006	.006	3	5
STOMACH	SCLY →	-1.220	-1.663	.004	.001	2	6
STOMACH	ATP5F1D →	-1.200	-2.147	.001	<.001	3	5
OVARY	RAPGEF3 →	+2.941	+1.326	<.001	<.001	3	5
LUNG_NSCLC_LUSC	IDH1 →	-1.835	-1.719	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042551 vs CST6 — LUNG_NSCLC_LUAD

Explore this scatter interactively →