Response to hydrogen peroxide

Across TCGA cell cohorts, RNA activity of the Response to hydrogen peroxide pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD46, TEX10, and CDKN1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD46 grouped by Response to hydrogen peroxide-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CD46 →	+0.766	+0.158	.004	.004	3	5
OESOPHAGUS	TEX10 →	-0.720	-0.209	.006	.001	3	5
SKIN	CDKN1A →	+2.037	+0.179	.002	.007	3	4
LUNG_SCLC	EML2 →	+1.210	+0.189	<.001	<.001	3	4
LUNG_SCLC	STK35 →	-0.694	-0.168	.001	.003	3	4
OVARY	SLC22A18 →	+1.073	+0.141	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD46 by Response to hydrogen peroxide activity — PANCREAS

Explore this box plot interactively →