Response to hydrogen peroxide

Across TCGA cell cohorts, RNA activity of the Response to hydrogen peroxide pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL22, ARHGEF40, and SOD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to hydrogen peroxide activity versus KLHL22 in LUNG_SCLC (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KLHL22 →	+1.117	+0.196	.001	<.001	3	5
LUNG_SCLC	ARHGEF40 →	+1.445	+0.149	.005	.008	2	6
LUNG_NSCLC_LUSC	SOD2 →	+2.017	+0.296	.002	.004	3	4
KIDNEY	CRTAP →	+1.032	+0.185	.007	.003	3	4
BLOOD_Leukemia	PLXND1 →	+1.447	+0.110	.002	.001	3	4
BLOOD_Leukemia	SLC66A2 →	+0.577	+0.142	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042542 vs KLHL22 — LUNG_SCLC

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