Hemoglobin biosynthetic process

Across TCGA patient cohorts, RNA activity of the Hemoglobin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRHL3-AS1, ABCA12, and ZNF462, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hemoglobin biosynthetic process activity versus GRHL3-AS1 in LSCC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GRHL3-AS1 →	+0.740	+0.546	.008	.002	3	4
LUAD	ABCA12 →	+0.680	+0.323	.004	.001	3	3
HNSC	ZNF462 →	+0.704	+0.167	.002	.009	2	4
LUAD	YEATS2 →	+0.393	+0.369	<.001	.004	2	4
LUAD	RN7SKP106 →	+0.497	+0.315	.006	.001	3	3
LUAD	CUX1 →	+0.277	+0.312	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042541 vs GRHL3-AS1 — LSCC

Explore this scatter interactively →