Hemoglobin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Hemoglobin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSSK6, ACD, and SMARCC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSSK6 grouped by Hemoglobin biosynthetic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TSSK6 →	-0.380	-0.919	<.001	.003	3	4
LIVER	ACD →	+1.007	+1.471	.007	<.001	3	4
LIVER	SMARCC1 →	-0.944	-1.614	.001	.006	2	5
BONE	TGS1 →	-1.264	-2.238	.001	<.001	3	3
BONE	GTF3C6 →	-0.795	-2.105	.009	<.001	3	3
BONE	CSNK2A3 →	-0.886	-1.910	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSSK6 by Hemoglobin biosynthetic process activity — CNS

Explore this box plot interactively →