Hemoglobin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Hemoglobin biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP2R3C, EDARADD, and GABRA5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP2R3C grouped by Hemoglobin biosynthetic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPP2R3C →	+0.240	+0.224	.005	.004	2	6
BONE	EDARADD →	-0.276	-0.347	.003	<.001	3	4
BLOOD_Myeloma	GABRA5 →	+0.127	+0.094	.002	.003	3	4
BONE	PAG1 →	+0.366	+0.330	<.001	.009	3	3
UPPER_AERODIGESTIVE_TRACT	ERN2 →	-0.164	-0.223	.005	.005	3	3
BLOOD_Myeloma	VMP1 →	+0.322	+0.089	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP2R3C by Hemoglobin biosynthetic process activity — BLOOD_Leukemia

Explore this box plot interactively →