Hyperosmotic salinity response

Across TCGA patient cohorts, RNA activity of the Hyperosmotic salinity response pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAMSAP3_S334, TBC1D2B, and AUH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hyperosmotic salinity response activity versus CAMSAP3_S334 in HNSC (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CAMSAP3_S334 →	+0.567	+0.099	.001	<.001	3	6
HNSC	TBC1D2B →	-0.222	-0.067	<.001	<.001	3	6
GBM	AUH →	+0.442	+0.087	<.001	<.001	3	5
GBM	CDS1_S9 →	+1.642	+0.124	<.001	<.001	3	5
COAD	CORO2A →	+0.394	+0.058	<.001	<.001	3	5
PDAC	CPT2 →	+0.357	+0.073	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042538 vs CAMSAP3_S334 — HNSC

Explore this scatter interactively →