Hyperosmotic salinity response

Across TCGA patient cohorts, RNA activity of the Hyperosmotic salinity response pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFHD1, CASQ2, and MAN2A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hyperosmotic salinity response activity versus EFHD1 in UCEC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EFHD1 →	+1.034	+0.206	<.001	.007	3	7
HNSC	CASQ2 →	+1.457	+0.113	.001	.001	3	4
BRCA	MAN2A1 →	+0.584	+0.104	.001	.007	3	4
CCRCC	TRIM23 →	+0.249	+0.096	.004	.003	3	4
UCEC	CDC45 →	-0.843	-0.167	.005	.007	3	4
BRCA	CAB39L →	+0.917	+0.165	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042538 vs EFHD1 — UCEC

Explore this scatter interactively →