Hyperosmotic salinity response

Across TCGA cell cohorts, RNA activity of the Hyperosmotic salinity response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFKFB1, LYPLA2, and MGST2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PFKFB1 grouped by Hyperosmotic salinity response-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PFKFB1 →	-0.124	-0.161	<.001	<.001	3	5
LUNG_SCLC	LYPLA2 →	+0.722	+0.230	.003	.003	3	5
URINARY_TRACT	MGST2 →	+3.317	+0.225	.009	.003	3	4
PANCREAS	TRIM14 →	+1.263	+0.211	.001	.001	3	4
LUNG_NSCLC_LUAD	AAK1 →	-0.887	-0.154	<.001	.001	3	4
LUNG_SCLC	EXOC6B →	-0.681	-0.146	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PFKFB1 by Hyperosmotic salinity response activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →