Hyperosmotic salinity response

Across TCGA cell cohorts, RNA activity of the Hyperosmotic salinity response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1B1, FBP1, and CCDC136, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hyperosmotic salinity response activity versus AKR1B1 in LUNG_NSCLC_LUAD (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AKR1B1 →	+3.883	+0.235	<.001	<.001	3	15
STOMACH	FBP1 →	-2.921	-0.161	<.001	<.001	3	12
BONE	CCDC136 →	+1.597	+0.141	<.001	.004	3	10
BLOOD_Leukemia	ADAP1 →	-1.394	-0.151	.003	.001	3	9
OESOPHAGUS	RIPK3 →	-1.928	-0.223	.009	.001	3	9
LUNG_NSCLC_LUAD	ANTXR1 →	+2.643	+0.186	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042538 vs AKR1B1 — LUNG_NSCLC_LUAD

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