Hyperosmotic salinity response

Across TCGA cell cohorts, RNA activity of the Hyperosmotic salinity response pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIEZO2, NIT2, and ORC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hyperosmotic salinity response activity versus PIEZO2 in SKIN (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PIEZO2 →	+3.425	+0.279	<.001	<.001	2	4
BREAST	NIT2 →	+0.852	+0.288	<.001	.004	3	3
LARGE_INTESTINE	ORC3 →	+0.871	+0.352	.002	.001	3	3
LUNG_SCLC	TNIP2 →	-0.928	-0.292	.006	<.001	3	3
LUNG_SCLC	TMEM86B →	-0.966	-0.292	<.001	<.001	3	3
OVARY	TNNT1 →	-7.040	-0.802	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042538 vs PIEZO2 — SKIN

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