Benzene-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Benzene-containing compound metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HCLS1, STK10, and GIMAP8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Benzene-containing compound metabolic process activity versus HCLS1 in UCEC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HCLS1 →	+0.567	+0.070	<.001	<.001	3	7
OV	STK10 →	+0.331	+0.045	.003	<.001	3	6
GBM	GIMAP8 →	+0.433	+0.060	.003	.002	3	6
OV	NCKAP1L →	+0.419	+0.046	.007	<.001	3	6
LUAD	FYB1 →	+0.519	+0.045	<.001	<.001	3	6
LUAD	LCP1 →	+0.413	+0.061	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042537 vs HCLS1 — UCEC

Explore this scatter interactively →