Benzene-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Benzene-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTM1, FGD2, and BTK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Benzene-containing compound metabolic process activity versus GSTM1 in COAD (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GSTM1 →	+1.410	+0.199	<.001	<.001	3	7
LSCC	FGD2 →	+0.635	+0.154	<.001	.005	3	6
OV	BTK →	+0.721	+0.215	.004	.003	3	6
OV	P2RY8 →	+0.788	+0.223	.002	.003	3	6
OV	SLAMF6 →	+1.087	+0.248	<.001	<.001	3	6
BRCA	HLA-DQB1-AS1 →	+1.208	+0.237	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042537 vs GSTM1 — COAD

Explore this scatter interactively →