Benzene-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Benzene-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IKBKG, CEP126, and IK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IKBKG grouped by Benzene-containing compound metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IKBKG →	+0.667	+1.025	.006	.002	3	5
LUNG_NSCLC_LUSC	CEP126 →	+0.889	+1.272	<.001	<.001	3	4
OESOPHAGUS	IK →	+0.743	+1.838	<.001	<.001	3	4
PANCREAS	WDTC1 →	+0.784	+1.085	<.001	.001	3	4
OESOPHAGUS	ZNF687 →	+0.911	+1.406	<.001	.004	3	4
OESOPHAGUS	GNG10 →	+1.111	+1.508	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IKBKG by Benzene-containing compound metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →