Benzene-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Benzene-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DGCR6, MAFG, and SLC19A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Benzene-containing compound metabolic process activity versus DGCR6 in BLOOD_Leukemia (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DGCR6 →	+1.114	+0.780	<.001	<.001	3	5
STOMACH	MAFG →	-1.006	-1.142	.003	.009	2	5
BLOOD_Leukemia	SLC19A2 →	+1.138	+0.907	<.001	<.001	3	4
BREAST	CSGALNACT2 →	-0.738	-0.826	.002	<.001	2	5
LUNG_NSCLC_LUAD	FHL1 →	-2.587	-0.795	.004	.008	3	4
STOMACH	TMEM265 →	+2.848	+1.356	.005	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042537 vs DGCR6 — BLOOD_Leukemia

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