Negative regulation of tyrosine phosphorylation of STAT protein

Across TCGA patient cohorts, RNA activity of the Negative regulation of tyrosine phosphorylation of STAT protein pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA4, TRIM22, and RASA2, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of tyrosine phosphorylation of STAT protein activity versus ITGA4 in DLBC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	ITGA4 →	+1.599	+0.064	<.001	<.001	3	32
UVM	TRIM22 →	+1.850	+0.059	<.001	<.001	3	31
DLBC	RASA2 →	+1.072	+0.059	<.001	<.001	3	31
UVM	PARP14 →	+1.516	+0.059	<.001	<.001	3	31
SKCM	PTPRC →	+1.783	+0.057	<.001	<.001	3	31
DLBC	ITK →	+1.694	+0.064	<.001	.002	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042532 vs ITGA4 — DLBC

Explore this scatter interactively →