Negative regulation of tyrosine phosphorylation of STAT protein

Across TCGA cell cohorts, RNA activity of the Negative regulation of tyrosine phosphorylation of STAT protein pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUSD5, BST1, and FAM50B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SUSD5 grouped by Negative regulation of tyrosine phosphorylation of STAT protein-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SUSD5 →	-1.367	-1.015	.001	.001	3	4
CNS	BST1 →	-1.336	-0.913	.002	.001	3	4
BLOOD_Leukemia	FAM50B →	-1.458	-1.201	.007	.009	3	4
OVARY	ZFP90 →	+1.150	+0.990	.002	.002	3	4
BREAST	MBTD1 →	+0.488	+0.824	.009	.001	3	4
BREAST	ADGRE5 →	-1.702	-1.101	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SUSD5 by Negative regulation of tyrosine phosphorylation of STAT protein activity — LUNG_SCLC

Explore this box plot interactively →