Negative regulation of tyrosine phosphorylation of STAT protein

Across TCGA cell cohorts, RNA activity of the Negative regulation of tyrosine phosphorylation of STAT protein pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPM2, OSCP1, and PSRC1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of tyrosine phosphorylation of STAT protein activity versus TPM2 in BLOOD_Leukemia (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TPM2 →	+1.598	+0.352	.003	.002	3	2
BLOOD_Leukemia	OSCP1 →	+1.178	+0.449	.002	.004	3	2
BLOOD_Leukemia	PSRC1 →	+1.438	+0.366	.005	.001	3	2
BLOOD_Leukemia	CEP112 →	+1.869	+0.420	<.001	<.001	3	2
BLOOD_Leukemia	NEMP1 →	+0.759	+0.358	.005	.002	3	2
BLOOD_Lymphoma	SLA →	+5.185	+0.344	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042532 vs TPM2 — BLOOD_Leukemia

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