Positive regulation of tyrosine phosphorylation of STAT protein

Across TCGA patient cohorts, RNA activity of the Positive regulation of tyrosine phosphorylation of STAT protein pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCF1, PTPRJ, and VSIR, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of tyrosine phosphorylation of STAT protein activity versus NCF1 in GBM (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCF1 →	+0.686	+0.053	<.001	<.001	3	8
COAD	PTPRJ →	+0.511	+0.032	.001	<.001	3	8
GBM	VSIR →	+0.527	+0.059	<.001	<.001	3	7
UCEC	AHNAK2_S260 →	+1.137	+0.050	.001	.006	3	7
OV	JUNB →	+0.434	+0.059	<.001	<.001	3	7
GBM	MNDA →	+0.822	+0.065	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042531 vs NCF1 — GBM

Explore this scatter interactively →