Positive regulation of tyrosine phosphorylation of STAT protein

Across TCGA patient cohorts, RNA activity of the Positive regulation of tyrosine phosphorylation of STAT protein pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALOX5, PLEKHO2_T364, and SLC29A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of tyrosine phosphorylation of STAT protein activity versus ALOX5 in LSCC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ALOX5 →	+0.428	+0.153	<.001	.004	3	4
HNSC	PLEKHO2_T364 →	+0.399	+0.207	<.001	.001	3	4
PDAC	SLC29A1 →	+0.863	+0.221	.002	.002	3	3
COAD	PPP4R2_S159 →	+0.264	+0.356	<.001	<.001	3	3
LUAD	CGAS_S143 →	+0.611	+0.350	.001	<.001	3	3
LSCC	AKAP1 →	-0.374	-0.175	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042531 vs ALOX5 — LSCC

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