Positive regulation of tyrosine phosphorylation of STAT protein

Across TCGA cell cohorts, RNA activity of the Positive regulation of tyrosine phosphorylation of STAT protein pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF14, C20orf173, and LGR6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF14 grouped by Positive regulation of tyrosine phosphorylation of STAT protein-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZNF14 →	+0.271	+0.441	.004	<.001	3	3
OESOPHAGUS	C20orf173 →	+0.190	+1.802	.005	<.001	3	3
OESOPHAGUS	LGR6 →	+0.180	+1.786	.004	<.001	3	3
BREAST	ORC4 →	+0.205	+0.462	.004	.008	3	2
BREAST	KIF5A →	+0.163	+0.556	.006	.002	3	2
BREAST	CHRM2 →	+0.154	+0.485	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF14 by Positive regulation of tyrosine phosphorylation of STAT protein activity — BREAST

Explore this box plot interactively →