Positive regulation of tyrosine phosphorylation of STAT protein

Across TCGA cell cohorts, RNA activity of the Positive regulation of tyrosine phosphorylation of STAT protein pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HROB, RBMS2, and IL18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of tyrosine phosphorylation of STAT protein activity versus HROB in BREAST (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HROB →	+0.931	+0.396	<.001	.004	3	4
LARGE_INTESTINE	RBMS2 →	+1.313	+1.008	<.001	.003	3	4
LUNG_NSCLC_LUAD	IL18 →	+1.535	+1.680	<.001	<.001	3	4
BLOOD_Leukemia	SHB →	+0.857	+0.621	.003	.005	3	3
BLOOD_Leukemia	MAPKAPK3 →	+0.973	+0.661	.003	.002	3	3
BLOOD_Leukemia	CERS2 →	+0.671	+0.835	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042531 vs HROB — BREAST

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