Gamma-delta T cell differentiation

Across TCGA patient cohorts, RNA activity of the Gamma-delta T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA4, EGR3, and CXorf21, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-delta T cell differentiation activity versus ITGA4 in DLBC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	ITGA4 →	+1.682	+0.068	<.001	.001	3	29
BRCA	EGR3 →	+1.611	+0.062	<.001	<.001	3	29
DLBC	CXorf21 →	+1.286	+0.081	.002	.002	2	29
THYM	PTPN22 →	+1.482	+0.148	<.001	<.001	3	28
THYM	LEF1 →	+3.302	+0.173	<.001	<.001	3	28
THYM	FERMT3 →	+1.375	+0.142	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042492 vs ITGA4 — DLBC

Explore this scatter interactively →