Gamma-delta T cell differentiation

Across TCGA patient cohorts, RNA activity of the Gamma-delta T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCR2P1, LINC01863, and MAGI1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-delta T cell differentiation activity versus CXCR2P1 in HNSC (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CXCR2P1 →	+0.970	+0.529	<.001	.007	3	4
LSCC	LINC01863 →	+0.391	+0.689	<.001	.005	3	3
CCRCC	MAGI1 →	-0.729	-0.688	.001	.002	3	3
HNSC	NCF1C →	+0.672	+0.633	<.001	.006	3	3
GBM	NOD2 →	+0.623	+0.460	<.001	.003	3	3
HNSC	FMNL1 →	+0.630	+0.712	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042492 vs CXCR2P1 — HNSC

Explore this scatter interactively →