Gamma-delta T cell differentiation

Across TCGA patient cohorts, RNA activity of the Gamma-delta T cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RGL2_S736, AXIN1, and ZC3HC1_S335, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-delta T cell differentiation activity versus RGL2_S736 in UCEC (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RGL2_S736 →	-1.118	-1.394	<.001	<.001	2	4
LSCC	AXIN1 →	-0.370	-0.717	<.001	.001	3	3
UCEC	ZC3HC1_S335 →	+0.660	+0.991	<.001	<.001	3	3
LSCC	SAMD14_S130 →	-0.808	-1.361	.002	<.001	3	2
LSCC	SRRM2_S508 →	+0.333	+1.057	.001	<.001	3	2
BRCA	TBC1D10A_S383 →	-0.357	-0.504	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042492 vs RGL2_S736 — UCEC

Explore this scatter interactively →