Inner ear auditory receptor cell differentiation

Across TCGA patient cohorts, RNA activity of the Inner ear auditory receptor cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITIH1, RPL5, and C8A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inner ear auditory receptor cell differentiation activity versus ITIH1 in CCRCC (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ITIH1 →	+0.591	+0.052	<.001	<.001	3	5
CCRCC	RPL5 →	-0.173	-0.037	.002	.005	3	5
BRCA	C8A →	+0.409	+0.027	.008	.003	3	5
OV	C8G →	+0.520	+0.034	.001	.006	3	5
CCRCC	ANGPTL2 →	+0.688	+0.050	<.001	<.001	3	5
CCRCC	NES →	+0.419	+0.039	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042491 vs ITIH1 — CCRCC

Explore this scatter interactively →