Inner ear auditory receptor cell differentiation

Across TCGA patient cohorts, RNA activity of the Inner ear auditory receptor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R16A, CCN1, and MSANTD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inner ear auditory receptor cell differentiation activity versus PPP1R16A in PDAC (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PPP1R16A →	+0.349	+0.334	<.001	.008	3	4
CCRCC	CCN1 →	-1.040	-0.487	<.001	<.001	3	3
CCRCC	MSANTD1 →	-0.122	-0.301	.005	.007	3	3
OV	LINC02664 →	-0.107	-0.184	.001	.002	3	3
COAD	MKRN1 →	+0.270	+0.728	<.001	.001	3	3
COAD	SP110 →	-0.506	-0.689	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042491 vs PPP1R16A — PDAC

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