Inner ear auditory receptor cell differentiation

Across TCGA cell cohorts, RNA activity of the Inner ear auditory receptor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMBIM1, TLE5, and CYP2S1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMBIM1 grouped by Inner ear auditory receptor cell differentiation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TMBIM1 →	+0.727	+0.217	.009	.003	2	5
URINARY_TRACT	TLE5 →	-0.919	-0.204	.004	.005	3	4
BONE	CYP2S1 →	-2.024	-0.482	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	ATXN10 →	-1.219	-0.222	.007	.003	2	4
UPPER_AERODIGESTIVE_TRACT	MAF1 →	-0.870	-0.144	.008	.003	3	3
SOFT_TISSUE	RNGTT →	+0.484	+0.179	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMBIM1 by Inner ear auditory receptor cell differentiation activity — KIDNEY

Explore this box plot interactively →