Inner ear auditory receptor cell differentiation

Across TCGA cell cohorts, RNA activity of the Inner ear auditory receptor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLS1, RAB6B, and CCDC74A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inner ear auditory receptor cell differentiation activity versus PLS1 in LUNG_NSCLC_LUAD (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PLS1 →	+0.880	+0.558	.001	.007	3	5
STOMACH	RAB6B →	-1.489	-0.311	.006	.005	3	5
LUNG_NSCLC_LUAD	CCDC74A →	-1.541	-0.660	.006	.008	3	4
UPPER_AERODIGESTIVE_TRACT	OTUD1 →	-1.414	-1.322	.003	.004	3	4
UPPER_AERODIGESTIVE_TRACT	KIF26A →	-0.905	-1.205	.002	.002	3	4
BLOOD_Leukemia	SNAI3 →	+1.084	+0.188	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042491 vs PLS1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →