Positive regulation of odontogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of odontogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RANBP2, NID2, and RCSD1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of odontogenesis activity versus RANBP2 in GBM (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RANBP2 →	-0.218	-0.090	<.001	<.001	3	9
GBM	NID2 →	+0.595	+0.119	<.001	<.001	3	9
GBM	RCSD1 →	+0.525	+0.092	<.001	<.001	3	8
LSCC	DHX9 →	-0.330	-0.118	<.001	<.001	3	8
LSCC	GIMAP7 →	+0.505	+0.085	<.001	<.001	3	8
GBM	ALYREF →	-0.376	-0.112	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042482 vs RANBP2 — GBM

Explore this scatter interactively →