Positive regulation of odontogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of odontogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NGFR, SRPX, and PLAC9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of odontogenesis activity versus NGFR in LSCC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NGFR →	+1.241	+0.739	<.001	<.001	3	6
CCRCC	SRPX →	+0.868	+0.578	<.001	.005	3	5
BRCA	PLAC9 →	+0.878	+0.577	.005	.005	3	4
BRCA	CHRDL1 →	+1.638	+0.673	<.001	<.001	3	4
PDAC	ASPA →	+0.621	+0.835	<.001	<.001	3	4
CCRCC	PTGIS →	+0.996	+0.516	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042482 vs NGFR — LSCC

Explore this scatter interactively →