Positive regulation of odontogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of odontogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR75, DNAH17, and MCM4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPR75 grouped by Positive regulation of odontogenesis-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GPR75 →	+0.195	+1.323	.002	<.001	3	4
STOMACH	DNAH17 →	+0.222	+2.010	.005	<.001	3	4
SOFT_TISSUE	MCM4 →	-0.224	-1.742	.005	<.001	3	4
BONE	EPHA2 →	-0.326	-1.395	.005	.001	3	4
LUNG_NSCLC_LUSC	NEURL4 →	+0.298	+1.728	.008	<.001	3	4
LUNG_NSCLC_LUSC	MYO9A →	+0.120	+1.372	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPR75 by Positive regulation of odontogenesis activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →