Regulation of odontogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of odontogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIMAP8, OLFML3, and LMO2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of odontogenesis activity versus GIMAP8 in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GIMAP8 →	+0.628	+0.378	<.001	.001	3	6
UCEC	OLFML3 →	+1.046	+0.592	.001	.008	3	5
UCEC	LMO2 →	+0.644	+0.642	<.001	<.001	3	5
BRCA	ABCA9 →	+0.794	+0.388	<.001	<.001	3	5
BRCA	LINC00924 →	+0.385	+0.509	<.001	<.001	3	5
OV	TGFB3 →	+0.915	+0.942	.008	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042481 vs GIMAP8 — BRCA

Explore this scatter interactively →